An efficient hybrid kernel extreme learning machine approach for early diagnosis of Parkinson's disease

In this paper, we explore the potential of extreme learning machine (ELM) and kernel ELM (KELM) for early diagnosis of Parkinson’s disease (PD). In the proposed method, the key parameters including the number of hidden neuron and type of activation function in ELM, and the constant parameter C and kernel parameter γ in KELM are investigated in detail. With the obtained optimal parameters, ELM and KELM manage to train the optimal predictive models for PD diagnosis. In order to further improve the performance of ELM and KELM models, feature selection techniques are implemented prior to the construction of the classification models. The effectiveness of the proposed method has been rigorously evaluated against the PD data set in terms of classification accuracy, sensitivity, specificity and the area under the ROC (receiver operating characteristic) curve (AUC). Compared to the existing methods in previous studies, the proposed method has achieved very promising classification accuracy via 10-fold cross-validation (CV) analysis, with the highest accuracy of 96.47% and average accuracy of 95.97% over 10 runs of 10-fold CV.